COPYRIGHT ©2019 BY THOMBS RESEARCH TEAM. ALL RIGHTS RESERVED

In 2012, Dr. Thombs and Dr. Andrea Benedetti, Associate Professor at McGill, partnered with local and international experts to set up the DEPRESsion Screening Data (DEPRESSD) Project to gather and synthesize large datasets and evaluate the accuracy of depression screening tools using individual participant data meta-analyses (IPDMAs). To date, the project has obtained CIHR funding to conduct analyses on the most commonly used depression screening tools in primary care (PHQ-9), perinatal care (EPDS), hospital care (HADS) and geriatric care (GDS). This project will allow us to provide practitioners and policy-makers with accurate, unbiased estimates of diagnostic accuracy for the screening tools, in order to better inform decisions on screening policy. Funded by 6 CIHR grants, the DEPRESSD collaboration now includes over 230 investigators from over 40 countries with numbers growing as more data are accrued. Large datasets for conducting IPDMAs and as a unique data sharing platform for the PHQ-9 (58 studies; 17,357 participants), HADS (83 studies; 19,839 participants), and EPDS (51 studies; 20,349 participants) with updates in process, as well as a new dataset on the GDS in progress.

To learn more the DEPRESSD project, please visit the DEPRESSD website: https://www.depressd.ca/.

Co-Principal  Investigator :

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Andrea Benedetti

Team Members:

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Brooke Levis

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Ankur Krishnan

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Danielle Rice

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Chen He

Ying (Sheryl) Sun.JPG

Sheryl Sun

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Dipika  Neupane

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Yin Wu

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Parash Mani Bhandari

Mahrukh Imran

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Zelalem Negeri

Example Publications: 

(Names of members of research team staff and students in bold)

DEPRESSD publications: 

Levis B, Benedetti A, Thombs BD, and the DEPRESsion Screening Data (DEPRESSD) Collaboration (Riehm KE, Saadat N, Levis AW, Azar M, Rice DB, Chiovitti MJ, Sanchez TA, Boruff J, Cuijpers P, Gilbody S, Ioannidis JPA, Kloda LA, McMillan D, Patten SB, Shrier I, Ziegelstein RC, Akena DH, Arroll B, Ayalon L, Baradaran HR, Baron M, Bombardier CH, Butterworth P, Carter G, Chagas MH, Chan JCN, Clover K, Conwell Y, de Man-van Ginkel JM, Delgadillo J, Fann JR, Fischer FH, Fung D, Gelaye B, Goodyear-Smith F, Greeno CG, Hall BJ, Hambridge J, Harrison PA, Härter M, Hegerl U, Hides L, Hobfoll SE, Hudson M, Inagaki M, Ismail K, Jetté N, Khamseh ME, Kiely KM, Kwan Y, Liu SI, Lotrakul M, Loureiro SR, Löwe B, Marsh L, McGuire A, Mohd Sidik S, Munhoz TN, Muramatsu K, Osório FL, Patel V, Pence BW, Persoons P, Picardi A, Reuter K, Rooney AG, Santos IS, Shaaban J, Sidebottom A, Simning A, Stafford L, Sung SC, Tan PLL, Turner A, van der Feltz-Cornelis CM, van Weert HC, Vöhringer PA, White J, Whooley MA, Winkley K, Yamada M, and Zhang Y).The accuracy of the Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: An individual participant data meta-analysis. BMJ. 2019;365:l1476.

Ishihara M, Harel D, Levis B, Levis AW, Riehm KE, Saadat N, Azar M, Rice DB, Sanchez TA, Chiovitti MJ, Cuijpers P, Gilbody S, Ioannidis JPA, Kloda LA, McMillan D, Patten SB, Shrier I, Arroll B, Bombardier CH, Butterworth P, Carter G, Clover K, Conwell Y, Goodyear-Smith F, Greeno CG, Hambridge J, Harrison PA, Hudson M, Jetté N, Kiely KM, McGuire A, Pence BW, Rooney AG, Sidebottom A, Simning A, Turner A, White J, Whooley MA, Winkley K, Benedetti A, Thombs BD. Shortening self-report mental health symptom measures through optimal test assembly Methods: Development and validation of the Patient Health Questionnaire-Depression-4. Depression and Anxiety. 2019;36(1):82-92.

Benedetti A, Wu Y, Levis B, Wilchesky M, Boruff J, Ioannidis JPA, Patten SB, Cuijpers P, Shrier I, Gilbody S, Ismail Z, McMillan D, Mitchell N, Ziegelstein RC, Thombs BD. Diagnostic accuracy of the Geriatric Depression Scale-30, Geriatric Depression Scale-15, Geriatric Depression Scale-5, and Geriatric Depression Scale-4 for detecting major depression: Protocol for a systematic review and individual participant data meta-analysis. BMJ Open. 2018;8(12):e026598.

 

Levis B, Benedetti A, Riehm KE, Saadat N, Levis AW, Azar M, Rice DB, Chiovitti MJ, Sanchez TA, Cuijpers P, Gilbody S, Ioannidis JPA, Kloda LA, McMillan D, Patten SB, Shrier I, Steele RJ, Ziegelstein RC, Akena DH, Arroll B, Ayalon L, Baradaran HR, Baron M, Beraldi A, Bombardier CH, Butterworth P, Carter G, Chagas MH, Chan JCN, Cholera R, Chowdhary N, Clover K, Conwell Y, de Man-van Ginkel JM, Delgadillo J, Fann JR, Fischer FH, Fischler B, Fung D, Gelaye B, Goodyear-Smith F, Greeno CG, Hall BJ, Hambridge J, Harrison PA, Hegerl U, Hides L, Hobfoll SE, Hudson M, Hyphantis T, Inagaki M, Ismail K, Jetté N, Khamseh ME, Kiely KM, Lamers F, Liu S-I, Lotrakul M, Loureiro SR, Löwe B, March L, McGuire A, Sidik MS, Munhoz TN, Muramatsu K, Osório FL, Patel V, Pence BW, Persoons P, Picardi A, Rooney AG, Santos IS, Shaaban J, Sidebottom A, Simning A, Stafford L, Sung S, Tan PLL, Turner A, van der Feltz-Cornelis CM, van Weert HC, Vöhringer PA, White J, Whooley MA, Winkley K, Yamada M, Zhang Y, Thombs BD. Probability of major depression classification using semi-structured versus fully structured diagnostic interviews. Br J Psychiatry. 2018;212(6):377-385.

 

Levis B, Benedetti A, Levis AW, Ioannidis JPA, Shrier I, Cuijpers P, Gilbody S, Kloda LA, McMillan D, Patten SB, Steele RJ, Ziegelstein RC, Bombardier CH, de Lima Osório F, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Loureiro SR, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Wittkampf KA, Yeung AS, Thombs BD. Selective cutoff reporting in studies of diagnostic test accuracy: A comparison of conventional and individual patient data meta-analyses of the Patient Health Questionnaire-9 depression screening tool. Am J Epidemiol. 2017;185(10):954-964.

Simoneau G, Levis B, Cuijpers P, Ioannidis JPA, Patten SB, Shrier I, Bombardier CH, de Lima Osório F, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Wittkampf KA, Yeung AS, Thombs BD, Benedetti A. A comparison of bivariate, multivariate random-effects, and Poisson correlated gamma-frailty models to meta-analyze individual patient data of ordinal scale diagnostic tests. Biometrical Journal. 2017;59:1317-1338.

Thombs BD, Benedetti A, Kloda LA, Levis BAzar MRiehm KESaadat N, Cuijpers P, Gilbody S, Ioannidis JP, McMillan D, Patten SB, Shrier I, Steele RJ,  Ziegelstein RC, Loiselle CG, Henry M, Ismail Z, Mitchell N, Tonelli M. Diagnostic accuracy of the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) for detecting major depression: protocol for a systematic review and individual patient data meta-analyses. BMJ Open. 2016 Apr 13;6:e011913.

Thombs BD, Benedetti A, Kloda LA, Levis BRiehm KEAzar M, Cuijpers P, Gilbody S, Ioannidis JPA, McMillan D, Patten SB, Shrier I, Steele RJ, Ziegelstein RC, Tonelli M, Mitchell N, Comeau L, Schinazi J, Vigod S. Diagnostic accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for detecting major depression in pregnant and postnatal women: protocol for a systematic review and individual patient data meta-analyses. BMJ Open. 2015 Oct;5:e009742.

Thombs BD, Benedetti A, Kloda LA, Levis B, Nicolau I, Cuijpers P, Gilbody S, Ioannidis JPA, McMillan D, Patten SB, Shrier I, Steele RJ, Ziegelstein RC. The diagnostic accuracy of the Patient Health Questionnaire-2 (PHQ-2), Patient Health Questionnaire-8 (PHQ-8), and Patient Health Questionnaire-9 (PHQ-9) for detecting major depression: Protocol for a systematic review and individual patient data meta-analyses. Syst Rev. 2014;3:124.

Other publications related to depression and depression screening:

Thombs BD, Kwakkenbos L, Levis AW, Benedetti A. Addressing overestimation of the prevalence of depression prevalence based on self-report screening questionnaires. CMAJ. 2018;190:E44-49.

Roseman M, Riehm KE, Saadat N, Kloda LA, Boruff J, Ickowicz A, Baltzer F, Katz LY, Patten SB, Rousseau C, Thombs BD. Depression screening and health outcomes in children and adolescents: a systematic review. Can J Psychiatry. 2017;62(12):813-817.

 

Roseman M, Saadat N, Riehm KE, Kloda LA, Ickowicz A, Baltzer F, Katz LY, Patten SB, Rousseau C, Roy D, Thombs BD. Accuracy of depression screening tools to detect major depression in children and adolescents: A systematic review. Can J Psychiatry. 2016;61(12):746-757.

 

Thombs BD, Rice DB. Sample sizes and precision of estimates of sensitivity and specificity from primary studies on the diagnostic accuracy of depression screening tools: A survey of recently published studies. Int J Methods Psychiatr Res. 2016;25(2):145-152.

 

Thombs BD, Ziegelstein RC, Roseman M, Kloda LA, Ioannidis JPA. There are no randomized controlled trials that support the United States Preventive Services Task Force guideline on screening for depression in primary care: A systematic review. BMC Med. 2014;12(1):13.

 

Thombs BD, Ziegelstein RC. Does depression screening improve depression outcomes in primary care settings? BMJ. 2014;348:g1253.

 

Thombs BD, Arthurs E, El-Baalbaki G, Meijer A, Ziegelstein RC, Steele RJ. Risk of bias from inclusion of patients who already have diagnosis of or are undergoing treatment for depression in diagnostic accuracy studies of screening tools for depression: systematic review. BMJ. 2011;343:d4825.

Thombs BD, de Jonge P, Coyne JC, Whooley MA, Frasure-Smith N, Mitchell AJ, Zuidersma M, Eze-Nliam C, Bezerra B, Smith CG, Soderlund K, Ziegelstein RC. Depression screening and patient outcomes in cardiovascular care: A systematic review. JAMA. 2008;300(18):2161-2171.